Design and Performance Analysis of a Non-Standard EPICS Fast Controller

The large scientific projects present new technological challenges, such as the distributed control over a communication network. In particular, the middleware EPICS is the most extended communication standard in particle accelerators. The integration of modern control architectures in these EPICS networks is becoming common, as for example for the PXI/PXIe and xTCA hardware alternatives. In this work, a different integration procedure for PXIe real time controllers from National Instruments is proposed, using LabVIEW as the design tool. This methodology is considered and its performance is analyzed by means of a set of laboratory experiments. This control architecture is proposed for achieving the implementation requirements of the fast controllers, which need an important amount of computational power and signal processing capability, with a tight real-time demand. The present work studies the advantages and drawbacks of this methodology and presents its comprehensive evaluation by means of a laboratory test bench, designed for the application of systematic tests. These tests compare the proposed fast controller performance with a similar system implemented using an standard EPICS IOC provided by the CODAC system.Comment: This is the extended version of the Conference Record presented in the IEEE Real-Time Conference 2014, Nara, Japan. This paper has been submitted to the IEEE Transactions on Nuclear Scienc

New and Developing Research on Disparities in Discipline

This briefing paper describes the results of new research in the area of disciplinary disparities, and identifies remaining gaps in the literature that can guide researchers and funders of research. The brief is organized into two sections:1) What Have we Learned? Key New Research Findings describes research from leading scholars across the nation commissioned by The Center for Civil Rights Remedies at UCLA's Civil Rights Project with the support of the Collaborative, findings from projects supported by the Collaborative Funded Research Grant Program, and other new research on disproportionality in school discipline in the peer-reviewed literature.2) Future Research Needs describes gaps that remain in the research base. Although there has been considerable new knowledge generated in recent years, significant gaps remain, especially in identifying and evaluating intervention strategies that reduce inequity in discipline for all students

Blue organic seven segment display based on poly (9,9-dioctyfluorene)with β-phase emission

In this work, organic seven segment displays based on poly(9,9-dioctyfluorene), PFO, have been fabricated. PFO has consolidated as an attractive material for PLEDs due to its efficient blue emission [1] and high hole mobility. Additionally, PFO has a particular conformation, called β-phase associated to extended PFO chain conformation, which is of great interest for potential device applications because, among all others, it has the highest photoluminescence quantum efficiency [2] and the best colour stability [3]. The structure fabricated uses Indium Tin Oxide (ITO) as anode, Poly(3,4 -ethylenedioxythiophene) /poly(4- styrenesulfonate) (PEDOT:PSS) as hole transport layer and Ba:Al as cathode. After thoroughly cleaning the substrates (covered with ITO) a photolithography process is carried out in order to pattern the anode. Next, the organic layers (PEDOTT:PSS and PFO) are spin casted. Finally, metals (Ba~30 nm and Al~100 nm) are thermally evaporated in an atmosphere of 6x10 -6 Torr. PFO is dissolved in toluene at 1 % wt. A detailed description of the fabrication process can be found in [4]. Finally, the device is encapsulated (using an epoxy and a glass tap) and contacts are indium soldered on the pads. In figure 1, we can observe the shadow mask used for the anode photolitography process (left) and the final device lighting in a zero configuration (right)

How sails generate forces

We propose a new paradigm of the aerodynamics of sails that reconciles our understanding of the force generation mechanisms of both upwind and downwind sails, and that is applicable to both attached and separated flow conditions. Sail experience significant flow separation. Even when the flow appears to be attached, this is sometimes only in the time averaged sense. In these conditions, the underlining as- sumptions of thin airfoil theory and lifting line theory are violated. There is therefore a need to develop an intuitive understanding of the force generation mechanisms that does not rely on these assumptions. This paper aims to address this issue by proposing a new paradigm based on the impulse theory. The force generation mechanism can be intuitively associated with the vorticity field, which can be gathered with computational fluid dynamics or particle image velocimetry. This paradigm intuitively reconciles key results of traditional wing aerodynamics, and provides sail designers a measurable objective to modify a sail shape also in separated flow conditions. It will hopefully underpin both a deeper understanding of sail aerodynamics and the development of low order models for new design tools

A Study of the Electrophoretic Mobilities of Multiple Myeloma Proteins

Over a period of several years our laboratory has been carrying out electrophoretic analysis of plasma, serum and body fluids from individuals with various diseases. One disease in which we have been interested is that of multiple myeloma

@City : lecturas tecnológicas de Barcelona

El concepto de ciudad contemporánea, del que trata este artículo, rescata la influencia que tiene la tecnología cuando se piensa, se planifica y se vive en una ciudad. Tecnología y ciudad conforman un binomio que replantea las costumbres y las prácticas sociales, incluso puede determinar la manera mediante la cual se puede constituir la propia identidad. Es suficiente observar cómo han ido cambiando las interacciones sociales que se llevan a cabo en las calles, medios de transporte, formas de comprar, trabajar y divertirse, para establecer una relación estrecha entre la tecnología (concretamente TICS) y las formas que van adquiriendo las urbes. @City es un concepto que pensamos que refleja muy bien las propiedades emergentes de una ciudad actual, esto es, la convivencia de un espacio urbano virtual con uno presencial. Justamente el proyecto 22@Barcelona se ha consolidado como un proyecto que intenta reunir diferentes tipos de espacios. 22@Barcelona, como un barrio de @City, al conjuntar lo presencial con lo virtual crea una frontera incierta y difuminada entre ambos espacios. Otro factor que nos parece interesante y que retoma este artículo se refiere al hecho de poder reflexionar en torno al impacto que tiene esta creación de espacios con procesos psicosociales. Procesos que hablan, por ejemplo de la vida cotidiana de un barrio, tradicionalmente obrero y ahora fuertemente demarcado por ejes tecnológicos.This article is about the concept of the contemporary city - the influence that technology has when one thinks about, plans and lives in a city. The conjunction of technology and city reformulates customs and social practices; it can even determine the way one constitutes one's own identity. One can see how close the relation is between technology (specifically, TICS) and the structures of the city in a wide variety of situations: in social interactions on the street, in transport, and in ways of buying, of working and entertainment. "@City" is a concept that very well reflects the emergent properties of a current city, that is, the coexistence of a physical and a virtual urban space. The "22@Barcelona" project attempts to bring together different types of spaces. By combining the physical with the virtual, 22@Barcelona, as a neighborhood of @City, creates an uncertain and blurred border between both spaces. The article also examines the impact that these spaces have on the psycho-social processes involved in the daily life of a traditionally working-class neighborhood, now strongly limited by technological boundaries

Novel signaling pathways mediating reciprocal control of keratinocyte migration and wound epithelialization through M3 and M4 muscarinic receptors

To test the hypothesis that keratinocyte (KC) migration is modulated by distinct muscarinic acetylcholine (ACh) receptor subtypes, we inactivated signaling through specific receptors in in vitro and in vivo models of reepithelialization by subtype-selective antagonists, small interfering RNA, and gene knockout in mice. KC migration and wound reepithelialization were facilitated by M4 and inhibited by M3. Additional studies showed that M4 increases expression of “migratory” integrins α5β1, αVβ5, and αVβ6, whereas M3 up-regulates “sedentary” integrins α2β1 and α3β1. Inhibition of migration by M3 was mediated through Ca2+-dependent guanylyl cyclase–cyclic GMP–protein kinase G signaling pathway. The M4 effects resulted from inhibition of the inhibitory pathway involving the adenylyl cyclase–cyclic AMP–protein kinase A pathway. Both signaling pathways intersected at Rho, indicating that Rho kinase provides a common effector for M3 and M4 regulation of cell migration. These findings offer novel insights into the mechanisms of ACh-mediated modulation of KC migration and wound reepithelialization, and may aid the development of novel methods to promote wound healing

Pilot Study of a Multi-pronged Intervention using Social Norms and Priming to Improve Adherence to Antiretroviral Therapy and Retention in Care among Adults Living with HIV in Tanzania.

Interventions incorporating constructs from behavioral economics and psychology have the potential to enhance HIV 'treatment as prevention' (TasP) strategies. To test this hypothesis, we evaluated an intervention to improve antiretroviral therapy (ART) adherence based on the concepts of social norms and priming. We used tools from marketing research and patient-centered design to develop a combination intervention that included visual feedback about clinic-level retention in care, a self-relevant prime, and useful take-home items with the priming image. The intervention was implemented at two HIV primary clinics in Shinyanga, Tanzania in 2-week intervals for six months. We conducted a quasi-experimental pilot study with a random sample of exposed and unexposed adult patients living with HIV infection (PLHIV) to compare retention and the proportion of patients with medication possession ratio (MPR) ≥95% after six months. Intervention acceptability was determined with a convenience sample of 405 PLHIV at baseline (n = 189) and endline (n = 216). Medical records were reviewed for 438 PLHIV (320 intervention, 118 standard of care). In adjusted analyses, PLHIV exposed to the intervention were significantly more likely to be in care after 6 months (87% vs. 79%, adjusted odds ratio (ORa) = 1.73, 95% CI: 1.08, 2.78, p<0.05) and were more likely to achieve MPR≥95% (70% vs. 59%, OR = 1.51, 95% CI: 0.96, 2.37, p = 0.07). The intervention was associated with increases in staff support of treatment goals (100% vs. 95%, p = 0.01) and life goals (66% vs. 50%, p<0.01), the perceived likelihood of other patients' adherence (54% vs. 32%, p<0.01), support from other patients (71% vs. 60%, p = 0.03), and being very satisfied with care (53% vs. 35%, p<0.01). This novel intervention has the potential to improve the clinic experience, short-term retention in care, and ART adherence. Future studies are needed to expand the generalizability of the approach and evaluate effectiveness on clinical outcomes

Costs and economies of scale in the accelerated program for prevention of mother-to-child transmission of HIV in Zimbabwe

Background Despite a growing body of literature on HIV service costs in sub-Saharan Africa, only a few studies have estimated the facility-level cost of prevention of Mother-to-Child Transmission (PMTCT) services, and even fewer provide insights into the variation of PMTCT costs across facilities. In this study, we present the first empirical costs estimation of the accelerated program for the prevention of mother-to-child transmission of HIV in Zimbabwe and investigate the determinants of heterogeneity of the facility-level average cost per service. To understand such variation, we explored the association between average costs per service and supply-and demand-side characteristics, and quality of services. One aspect of the supply-side we explore carefully is the scale of production—which we define as the annual number of women tested or the yearly number of HIV-positive women on prophylaxis. Methods We collected rich data on the costs and PMTCT services provided by 157 health facilities out of 699 catchment areas in five provinces in Zimbabwe for 2013. In each health facility, we measured total costs and the number of women covered with PMTCT services and estimated the average cost per woman tested and the average cost per woman on either ARV prophylaxis or ART. We refer to these facility-level average costs per service as unitary costs. We also collected information on potential determinants of the variation of unitary costs. On the supply-side, we gathered data on the scale of production, staff composition and on the types of antenatal and family planning services provided. On the demand side, we measured the total population at the catchment area and surveyed eligible pairs of mothers and infants about previous use of HIV testing and prenatal care, and on the HIV status of both mothers and infants. We explored the determinants of unitary cost variation using a two-stage linear regression strategy. Results The average annual total cost of the PMTCT program per facility was US$16,821 (median US$8,920). The average cost per pregnant woman tested was US$80 (median US$47), and the average cost per HIV-positive pregnant woman initiated on ARV prophylaxis or treatment was US$786 annually (median US$420). We found substantial heterogeneity of unitary costs across facilities regardless of facility type. The scale of production was a strong predictor of unitary costs variation across facilities, with a negative and statistically significant correlation between the two variables (p<0.01). Conclusions These findings are the first empirical estimations of PMTCT costs in Zimbabwe. Unitary costs were found to be heterogeneous across health facilities, with evidence consistent with economies of scale